Prediction of Respiratory Morbidities in Late Preterm Neonates Using Cord Blood Arterial Lactate and Base Excess
نویسندگان
چکیده مقاله:
Background: Late preterm neonates may have the external appearance and behavior similar to their counterparts.However, they are susceptible to various neonatal morbidities , due to their physiological and metabolical immaturity.To assess the correlation between cord blood arterial lactate levels and base excess with the development ofrespiratory distress in late preterm neonates.Methods: All inborn neonates born at Kasturba hospital Manipal, satisfying the criteria of late preterm infants (34 -366/7 weeks) were included in this prospective observational study.The data recorded included gender, birth weight,multiple births, presence of major congenital anomalies, mode of delivery, APGAR score at minute 5, need forresuscitation, admission to the neonatal intensive care unit (NICU), and days of hospitalization. Lactate and base excesswere estimated using blood obtained from umbilical artery sampling. The primary outcome assessed was therequirement of delivery room resuscitation. The secondary outcomes assessed were the development of respiratorydistress, requirement of invasive/non- invasive ventilation, and respiratory support.Results: Cord blood base excess levels were significantly higher in late preterm neonates requiring delivery roomresuscitation compared to those who did not require resuscitation (median: -8 vs -4mEq/L, p-value: 0.002).In terms ofrespiratory morbidities, cord blood base excess levels were significantly higher in neonates with respiratory distresssyndrome (RDS)(median: -8.5 vs -3.4 mEq/L, p-value 0.001), and transient tachypnea of newborn (TTNB) (median: -8vs -3.4 mEq/L, p-value 0.004), compared to those without RDS and TTNB.However,there was no signi icant associationbetween cord blood lactate levels and the outcomes assessed.Conclusion: Estimation of arterial base excess levels obtained from umbilical cord blood sampling during delivery mayserve as a sensitive marker for predicting respiratory morbidities in late preterm neonates.
منابع مشابه
Investigating the Association of Cord Blood Resistin and Birth Weight in Term and Preterm Neonates
BackgroundResistin is reported as an antagonistic hormone of insulin and in the literature. Nowadays, importance of resistin is being more highlighted in the metabolism of mother and fetus during pregnancy. This study aimed to assess the level of resistin in the umbilical cord and blood sugar at birth and evaluate the association of resistin and neonatal birth weight.Materials and MethodsThis c...
متن کاملNeutrophil functions in late preterm neonates with respiratory distress syndrome
INTRODUCTION The innate immune system is the first line of host defense against invading microorganisms. In order to achieve this, neutrophils must be able both to circulate freely in the blood and to migrate as adherent cells into the extravascular tissues to phagocytose and kill invading microorganisms effectively. Most studies of neutrophil function have been conducted under conditions of am...
متن کاملinvestigating the association of cord blood resistin and birth weight in term and preterm neonates
backgroundresistin is reported as an antagonistic hormone of insulin and in the literature. nowadays, importance of resistin is being more highlighted in the metabolism of mother and fetus during pregnancy. this study aimed to assess the level of resistin in the umbilical cord and blood sugar at birth and evaluate the association of resistin and neonatal birth weight.materials and methodsthis c...
متن کاملImmune development in late preterm neonates
Several recent studies have underlined that late preterm infants have a significantly increased risk of infection and sepsis, [1-3] mainly related to problems of adaptation from intrato extra-uterine life of the immune defense mechanisms. Indeed, both the innate (natural, non specific) and the adaptive (acquired, specific) immune systems are incompletely developed at birth, the more preterm the...
متن کاملPeriventricular Hemorrhage in Term and Late Preterm Neonates: Risk Factors and Outcomes
Background: Periventricular hemorrhage (PVH) is common in early preterm neonates but much less common in term and late preterm neonates. The aim of this study was to identify the risk factors and outcomes of PVH in term and late preterm neonates in a tertiary care center in Upper Egypt. Methods: A total of 33 term and late preterm (≥ 34 weeks...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ذخیره در منابع من قبلا به منابع من ذحیره شده{@ msg_add @}
عنوان ژورنال
دوره 10 شماره 4
صفحات 71- 75
تاریخ انتشار 2019-11-01
با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023